The role of FHIT gene in lung carcinogenesis

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• 作者：Sozzi ; Gabriella ; Tornielli ; Silvana ; Sard ; Laura ; Musso ; Katia ; Veronese ; Maria Luisa ; Incarbone ; Matteo ; et. al.
• 刊名：Lung Cancer
• 出版年：1997
• 出版时间：August, 1997
• 年：1997
• 卷：18
• 期：Supplement 1
• 页码：151
• 全文大小：125 K

文摘

The FHIT gene, identified at 3p14.2, encompasses the FRA3B fragile site and is disrupted by the t(3;8) chromosomal translocation in familial renal cell carcinoma. FHIT is a member of the histidine triad gene family and encodes a dinucleoside 5′, 5-P1, P3-triphosphate hydrolase (Ap3A) which cleaves the diadenosine triphosphate into ADP and AMP.