Differential expression of calbindin in nigral dopaminergic neurons in two mice strains with differential susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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- 作者：D.J. Vidyadhara1 ; H. Yarreiphang1 ; P.L. Abhilash1 ; T.R. Raju ; Phalguni Anand Alladi ; alladiphalguni@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DA ; dopaminergic ; IR ; immunoreactive/immunoreactivity ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; PD ; Parkinson&rsquo ; s disease ; SNpc ; substantia nigra pars compacta ; TH ; tyrosine hydroxylase ; VTA ; ventral tegmental area
- 刊名：Journal of Chemical Neuroanatomy
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：76
- 期：part_PB
- 页码：82-89
- 全文大小：3483 K
文摘
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Calbindin, a decisive factor in differential susceptibility of mice strains to MPTP.
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Fewer calbindin expressing neurons in substantia nigra of C57BL/6 than CD-1 mice.
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Individual SNpc neuronal calbindin levels of CD-1 mice are higher than C57BL/6 mice.
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Sizeable proportion of CD-1 dopaminergic neurons express higher levels of calbindin.
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Higher protein expression in VTA, medial and dorsal nigra hint at regional resilience.