Antiproliferative effect and apoptotic activity of linear geranylphenol derivatives from phloroglucinol and orcinol
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- 作者：Lautaro Taborgaa ; 1 ; lautaro.taborga@usm.cl" class="auth_mail" title="E-mail the corresponding author ; Luis Espinozaa ; luis.espinozac@usm.cl" class="auth_mail" title="E-mail the corresponding author ; Alejandra Mollerb ; alejandra.moller@uv.cl" class="auth_mail" title="E-mail the corresponding author ; Hé ; ctor Carrascoc ; hector.carrasco@uautonoma.cl" class="auth_mail" title="E-mail the corresponding author ; Mauricio Cuellard ; mauricio.cuellar@uv.cl" class="auth_mail" title="E-mail the corresponding author ; Joan Villenab ; 1 ; juan.villena@uv.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytotoxic activity ; Cancer cell lines ; Apoptosis ; Mitochondrial membrane permeability ; Caspase-3 activity ; Linear geranylphenols
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：247
- 期：Complete
- 页码：22-29
- 全文大小：1174 K
文摘
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The phloroglucinol & orcinol derivatives show cytotoxicity against cancer cell lines.
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These compounds may induce apoptosis through activation of the mitochondrial pathway.
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The activity of these compounds depend of the amount of chains geranyl presents.
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The activity depend of the symmetry of substitution in the aromatic ring.