An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines

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• 作者：Marco Radi ; Vincenzo Bernardo ; Giulia Vignaroli ; Annalaura Brai ; Mariangela Biava ; Silvia Schenone ; Maurizio Botta
• 关键词：Pyrazolo[3 ; 4-d]pyrimidines ; N1-functionalization ; Microwave ; Antitumor
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：18 September, 2013
• 年：2013
• 卷：54
• 期：38
• 页码：5204-5206
• 全文大小：714 K

文摘

A versatile approach for the synthesis of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines has been developed. Starting from commercially available allopurinol, TBAF mediated N1-functionalization and subsequent C4 nucleophilic substitution, under microwave assisted- or standard heating conditions, granted access to highly functionalized pyrazolo[3,4-d]pyrimidines of potential biological interest.