receptors of the amygdala in modulating anxiety, rats were implanted with bilateral cannulae aimed at the basolateral nucleus of the amygdala complex and infused with either artificial cerebrospinal fluid (aCSF) or the selective 5-HT
receptor agonist 8-OH-DPAT (50–200 ng) and tested in two animal models of anxiety. In the elevated plus-maze test, no significant effects were detected in this dose range. In contrast, 8-OH-DPAT caused an overall reduction in levels of social investigation, thus indicating anxiogenic actions in the social interaction test. At 50 ng, 8-OH-DPAT had a selective action on anxiety, while at 200 ng there was a concomitant reduction in locomotor activity and, in some animals, signs of the 5-HT
syndrome. Evidence that the anxiogenic effect of 8-OH-DPAT (50 ng) was due to activation of 5-HT
receptor antagonist, reversed this effect at a dose (1.5 μg) which was silent when given alone. The benzodiazepine receptor agonist, midazolam (1 and 2 μg) was bilaterally administered into the basolateral nucleus of the amygdala and evoked clear-cut anxiolytic effects in the social interaction test. These data indicate that the agonist activation of post-synaptic 5-HT
receptors in the basolateral nucleus of the amygdala may produce anxiogenic effects, while agonist activation of BDZ receptors in the same areas evokes anxiolytic effects. Our results from the social interaction test are similar to those previously reported from tests of anxiety using punished paradigms, but contrast with those found in the elevated plus-maze. Thus, it is concluded that either the two tests have different sensitivities to midazolam and 8-OH-DPAT or more intriguingly, the tests are evoking fundamentally different states of anxiety, with that evoked by the plus-maze being mediated via brain areas or receptors different from those studied here.
Cited by: | - Rammes, G.; Eder, M.; Dodt, H.-U.; Kochs, E.; Zieglgansberger, W.,""Long-term depression in the basolateral amygdala of the mouse involves the activation of interneurons""Neuroscience2001pp. 85-97
Bibliographic PageFull Text - Pulgarin, Jose A. Murillo; Molina, Aurelia Alanon; Lopez, Pablo Fernandez,""Direct analysis of amiloride and triamterene mixtures by fluorescence spectrometry using partial-least squares calibration""Analytica Chimica Acta2001pp. 179-187
Bibliographic PageFull Text - Solich, Petr; Polydorou, Christoforos K.; Koupparis, Michael A.; Efstathiou, Constantinos E.,""Automated flow injection fluorimetric determination and dissolution studies of bumetanide in pharmaceuticals""Analytica Chimica Acta2001pp. 131-136
Bibliographic PageFull Text - Nakamura, Kazuo; Kurasawa, Mitsue,""Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism""European Journal of Pharmacology2001pp. 33-43
Bibliographic PageFull Text - Thieme, D.; Grosse, J.; Lang, R.; Mueller, R.K.; Wahl, A.,""Screening, confirmation and quantitation of diuretics in urine for doping control analysis by high-performance liquid chromatography-atmospheric pressure ionisation tandem mass spectrometry""Journal of Chromatography B: Biomedical Sciences and Applications2001pp. 49-57
Bibliographic PageFull Text - Deshpande, Laxmikant S.; Khisti, Rahul T.; Chopde, Chandrabhan T.,""Cataleptic effect of neurosteroid 3a-hydroxy-5a-pregnan-20-one in mice: modulation by serotonergic agents""Brain Research2001pp. 13-26
Bibliographic PageFull Text - de Paula Portela, Carlos; de Oliveira Massoco, Cristina; de Lima, Wothan Tavares; Palermo-Neto, Joao,""Stress-induced increment on total bronchoalveolar cell count in OVA-sensitized rats""Physiology and Behavior2001pp. 415-420
Bibliographic PageFull Text - Pulgarin, Jose A. Murillo; Molina, Aurelia Alanon; Lopez, Pablo Fernandez,""Simultaneous Direct Determination of Amiloride and Triamterene in Urine Using Isopotential Fluorometry""Analytical Biochemistry2001pp. 59-68
Bibliographic PageFull Text - Luis, M. Luz; Corujedo, Sara; Blanco, Domingo; Fraga, Jose M.G.; Jimenez, Ana I.; Jimenez, Francisco; Arias, Juan J.,""Micellar electrokinetic capillary chromatography analysis of diuretics in pharmaceutical formulations""Talanta2002pp. 223-231
Bibliographic PageFull Text - Dominguez-Vidal, A.; Ortega-Barrales, P.; Molina-Diaz, A.,""Determination of triamterene by transitory retention in a continuous flow solid phase system with fluorimetric transduction""Journal of Pharmaceutical and Biomedical Analysis2002pp. 721-728
Bibliographic PageFull Text - Canto-de-Souza, Azair; Luiz Nunes-de-Souza, Ricardo; John Rodgers, Robert,""Anxiolytic-like effect of way-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience""Brain Research2002pp. 50-59
Bibliographic PageFull Text - Horstkotter, Christian; Kober, Susan; Spahn-Langguth, Hildegard; Mutschler, Ernst; Blaschke, Gottfried,""Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using ultraviolet absorbance and laser-induced fluorescence detection""Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences2002pp. 107-117
Bibliographic PageFull Text - Nunes-de-Souza, Ricardo Luiz; Canto-de-Souza, Azair; Rodgers, Robert John,""Effects of intra-hippocampal infusion of WAY-100635 on plus-maze behavior in mice""Brain Research2002pp. 87-96
Bibliographic PageFull Text - Young, Larry J.,""The neurobiology of social recognition, approach, and avoidance""Biological Psychiatry2002pp. 18-26
Bibliographic PageFull Text - Gonzalez, Luis E.; File, Sandra E.; Overstreet, David H.,""Selectively Bred Lines of Rats Differ in Social Interaction and Hippocampal 5-HT1A Receptor Function: A Link Between Anxiety and Depression?""Pharmacology Biochemistry and Behavior1998pp. 787-792
Bibliographic PageFull Text - Millan, Mark J.; Brocco, Mauricette,""The Vogel conflict test: procedural aspects, g-aminobutyric acid, glutamate and monoamines""European Journal of Pharmacology2003pp. 67-96
Bibliographic PageFull Text - File, Sandra E.; Seth, Pallab,""A review of 25 years of the social interaction test""European Journal of Pharmacology2003pp. 35-53
Bibliographic PageFull Text - McCool, Brian A.; Frye, Gerald D.; Pulido, Marisa D.; Botting, Shaleen K.,""Effects of chronic ethanol consumption on rat GABAA and strychnine-sensitive glycine receptors expressed by lateral/basolateral amygdala neurons""Brain Research2003pp. 165-177
Bibliographic PageFull Text - Amendola, Luca; Colamonici, Cristiana; Mazzarino, Monica; Botre, Francesco,""Rapid determination of diuretics in human urine by gas chromatography-mass spectrometry following microwave assisted derivatization""Analytica Chimica Acta2003pp. 125-136
Bibliographic PageFull Text - Nic Dhonnchadha, Brid Aine; Bourin, Michel; Hascoet, Martine,""Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety""Behavioural Brain Research2003pp. 203-214
Bibliographic PageFull Text - Genn, Rachel F.; Tucci, Sonia A.; Thomas, Amy; Edwards, Jessica E.; File, Sandra E.,""Age-associated sex differences in response to food deprivation in two animal tests of anxiety""Neuroscience and Biobehavioral Reviews2003pp. 155-161
Bibliographic PageFull Text - Millan, Mark J.,""The neurobiology and control of anxious states""Progress in Neurobiology2003pp. 83-244
Bibliographic PageFull Text - Rangel, Alejandra; Gonzalez, Luis E.; Villarroel, Vanessa; Hernandez, Luis,""Anxiolysis followed by anxiogenesis relates to coping and corticosterone after medial prefrontal cortical damage in rats""Brain Research2003pp. 96-103
Bibliographic PageFull Text - Campbell, Brian M.; Merchant, Kalpana M.,""Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment""Brain Research2003pp. 1-9
Bibliographic PageFull Text - Thang To, C.; Bagdy, Gyorgy,""Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment1""Neuropharmacology1999pp. 279-282
Bibliographic PageFull Text - Kang-Park, M.-H.; Wilson, W.A.; Moore, S.D.,""Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei""Neuropharmacology2004pp. 1-9
Bibliographic PageFull Text - Kantor, Sandor; Anheuer, Zsuzsanna E.; Bagdy, Gyorgy,""High social anxiety and low aggression in Fawn-Hooded rats""Physiology and Behavior2000pp. 551-557
Bibliographic PageFull Text - Knapp, Darin J.; Sim-Selley, Laura J.; Breese, George R.; Overstreet, David H.,""Selective breeding of 5-HT1A receptor-mediated responses: application to emotion and receptor action""Pharmacology Biochemistry and Behavior2000pp. 701-708
Bibliographic PageFull Text - Caldji, Christian; Diorio, Josie; Meaney, Michael J.,""Variations in maternal care in infancy regulate the development of stress reactivity""Biological Psychiatry2000pp. 1164-1174
Bibliographic PageFull Text |