Tug of War in Spindle Orientation

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• 作者：Song Li¹ ; Hongyan Wang¹ ; ² ; ³ ; ^{hongyan.wang@duke-nus.edu.sg" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Developmental Cell
• 出版年：2016
• 出版时间：11 January 2016
• 年：2016
• 卷：36
• 期：1
• 页码：1-2
• 全文大小：188 K

文摘

The evolutionarily conserved Gαi-LGN-NuMA protein complex is a key regulator of spindle orientation, but how its spatiotemporal localization is achieved remains elusive. Chiu et al. (2016) show that SAPCD2 negatively regulates LGN cortical localization by competing with NuMA for LGN binding in both epithelial cells and mouse retinal progenitor cells.