- 作者：Omer Dizdar ; Hakan Harputluoglu ; Umit Tapan ; Kadri Altundag
- 关键词：A. Thin films ; B. Chemical synthesis ; B. Crystal growth
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2008
- 出版时间：1 April 2008
- 年：2008
- 卷：70
- 期：5
- 页码：1615
- 全文大小：57 K
Patients and methods
One hundred and eighty patients presenting 356 lesions were give first-line radiosurgery between 1995 and 2001 in Pitié-Salpêtrière hospital using a 10 MV LINAC. Mean age was 59 years, sex-ratio was 1.65, mean KI was 70. The lung was the most frequent primary site (n=85), followed by melanoma (n=29), kidney (n=21), digestive tract (n=14), breast (n=11), and others (n=20). Seventy-six percent of the patients presented 1 or 2 lesions. Mean tumor volume was 5.5cm3. Mean peripheral dose was 14.8Gy, mean isocenter dose was 21.6Gy.
Results
Median survival was 7.6 months, local control rate was 90 % at 6 months, 76 % at 1 year and 70 % at 2 years. Median “neurological disease free” survival was 15 months. Multivariate analysis demonstrated the influence of two parameters on survival : number of lesions (p=0.001) and KI (p=0.04). The only parameter significantly correlated with disease-free survival was the number of isocenters (p = 0.005). Morbidity (grade 2 RTOG) was 7.2 % with no perimortality.
Conclusions
Low peripheral doses delivered by radiosurgery may control brain metastases with the same efficacy and fewer side-effects as the doses usually reported in the literature.