Human LCs express a distinct S1P receptor profile.
Activation of S1P receptors does not induce complete maturation of human LCs but reduces cytokine release in mature LCs.
S1P is a chemoattractant for LCs and reduces migration of immature and mature MUTZ-LCs but not MoLCs.
Exogenous and endogenous S1P signalling is dispensable for LC endocytosis.