Continuous succinic acid fermentation by Escherichia coli KJ122 with cell recycle
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- 作者：Adolf Krige ; Willie Nicol ; willie.nicol@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Succinic acid ; E. coli ; Continuous cell recycle ; High-cell-density fermentation ; Metabolic flux analysis
- 刊名：Process Biochemistry
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：50
- 期：12
- 页码：2004-2011
- 全文大小：1070 K
文摘
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Productivity of 3 g L−1 h−1 and yield of 0.77 g g−1 achieved at D = 0.15 h−1.
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Increased pyruvate dehydrogenase activity at higher D contributes to yield increase.
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Minimal oxidative TCA/glyoxylate flux detected from analysis.
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Batch results inferior in productivity but superior in yield and titre.