The expression of CiPKR and CiPKZ were significantly increased following Poly I:C stimulation.
CiIRF3 bound to the promoters of CiPKR and CiPKZ with high affinity in vitro.
CiIRF3 was able to up-regulate the transcriptional level of CiPKR and CiPKZ in vivo.
ISRE was an important component but not the only element in the transcriptional initiation of CiPKR and CiPKZ.