Depletion of ATF4 decreased SREBP1c protein while increased Srebp1c mRNA.
USP7 was identified as a novel target of ATF4.
USP7 deubiquitinated SREBP1c protein and increased its level in cell.
ATF4 inhibited Srebp1c transcription via TRB3.
TRB3 was repressed by IBMX and DEX at early adipogenesis.