Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus
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- 作者：Feifei Zhanga ; b ; 1 ; Lingling Wua ; 1 ; Jie Qiana ; 1 ; Bo Qua ; Shiwei Xiaa ; Ting Lab ; Yanfang Wua ; Jianyang Maa ; Jing Zenga ; Qiang Guoa ; Yong Cuid ; Wanling Yange ; Jiaqi Huangf ; Wei Zhuf ; Yihong Yaof ; Nan Shena ; b ; c ; nanshensibs@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yuanjia Tanga ; b ; tangyuanjia028@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Long noncoding RNA ; NEAT1 ; TLR4 ; Systemic lupus erythematosus ; Cytokines
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：96-104
- 全文大小：1561 K
文摘
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Long noncoding RNA NEAT1 is an early-response gene in response to innate immune ligand and its abnormal expression is associated with SLE patients.
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NEAT1 plays an important role on regulating TLR mediated inflammatory pathway and the expression of a group of chemokines and cytokines.
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We also emphasize the clinical implication by showing the correlation of NEAT1 and disease activity and clinical manifestations in SLE patients.