A53T α-synuclein could decrease neurite outgrowth with enhanced Rho kinase activity.
Fasudil could attenuate the neurite outgrowth injury caused by A53T α-synuclein.
Fasudil could promote the autophagic degradation of A53T α-synuclein.
The effect of fasudil was mediated by JNK/Bcl-2/beclin 1/Vps34 pathway.