Probiotics in functional bowel disorders

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• 作者：Keren Hod ; PhD^a (Candidate in Epidemiology ; Clinical Nutritionist) ; Yehuda Ringel ; MD^b ; ^c ; (Professor of Medicine)
• 关键词：Probiotics ; Functional bowel disorders ; Irritable bowel syndrome ; Intestinal mocrobiota
• 刊名：Best Practice & Research Clinical Gastroenterology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：30
• 期：1
• 页码：89-97
• 全文大小：288 K

文摘

Functional bowel disorders (FBDs) are the most common gastrointestinal (GI) disorders seen by gastroenterologists and primary care physicians. The disorders affect patients functioning and quality of life (QOL) and are associated with significant healthcare burden. The current theory regarding the development of FBDs suggests brain-gut axis dysfunctions associated abnormal GI motility and sensation. Recent data suggest that alterations in the intestinal microbiota may have a role in the pathogenesis of FBDs; or at least have the potential to affect intestinal functions that are thought to be relevant to the development of functional GI symptoms. This has led to growing interest of healthcare providers and patients in targeting the intestinal microbiota for the treatment of FBDs. In this article we discuss the potential role probiotic interventions in the treatment of FBDs. We review the evidence from pre-clinical and clinical studies and discuss the current recommendations for the use of probiotics for FBDs in clinical practice.