A small molecule inhibitor of NF-κB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells
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- 作者：Jason Ho Ting Wong ; Vivian Wai Yan Lui ; Kazuo Umezawa ; Yeung Ho ; Elaine Yue Ling Wong ; Margaret Heung Ling Ng ; Suk Hang Cheng ; Chi Man Tsang ; Sai Wah Tsao ; Anthony Tak Cheung Chan
- 关键词：NF-κ ; B inhibitor ; DHMEQ ; Nasopharyngeal carcinoma ; Anti-proliferation ; Anti-invasion ; Apoptosis
- 刊名：Cancer Letters
- 出版年：2010
- 出版时间：1 January 2010
- 年：2010
- 卷：287
- 期：1
- 页码：23-32
- 全文大小：1971 K
文摘
Despite the demonstrated constitutive activation of NF-κB in nasopharyngeal carcinoma (NPC), the therapeutic potential of targeting this pathway has not been investigated. Here, we employed a small molecule inhibitor of NF-κB, DHMEQ (which mainly blocks nuclear translocation of activated NF-κB) and demonstrated significant inhibition of NPC cell proliferation, migration, invasion, as well as anchorage-independent growth. These antitumor effects were associated with induction of G2/M cell cycle arrest and apoptosis, and downregulation of NF-κB target genes (EGFR, cyclin D1 and survivin). This first demonstration of therapeutic benefits of NF-κB targeting in NPC implicates the importance of targeting this pathway in NPC.