Infection Imaging With ¹⁸F-FDS and First-in-Human Evaluation

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• 作者：Shaobo Yao^a ; ¹ ; Haiqun Xing^a ; ¹ ; Wenjia Zhu^a ; Zhanhong Wu^b ; Yingqiang Zhang^a ; Yanru Ma^a ; Yimin Liu^a ; Li Huo^a ; Zhaohui Zhu^a ; Zibo Li^b ; Fang Li^a ; ^{lifang@pumch.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Automated synthesis ; 18F-FDS ; Infection ; Gram-negative bacteria ; PET
• 刊名：Nuclear Medicine and Biology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：43
• 期：3
• 页码：206-214
• 全文大小：1409 K

文摘

The noninvasive imaging of bacterial infections is critical in order to reduce mortality and morbidity caused by these diseases. The recently reported ¹⁸F-FDS (¹⁸F-2-fluorodeoxy sorbitol) as a PET (positron emission tomography) tracer can be used to image Enterobacteriaceae-specific infections and provides a potential alternative to this problem compared with other probes for imaging infections. In this study, automatic synthesis, validation of ¹⁸F-FDS and a first-in-human study were performed and discussed.

Methods

A multifunctional synthesis module was employed for the radiosynthesis of ¹⁸F-FDG (¹⁸F-2-fluorodeoxy glucose) and ¹⁸F-FDS starting from ¹⁸F ion using two-pot three-step fully automated reactions. The behavior of ¹⁸F-FDS as an in vivo imaging probe for infections was evaluated in an Escherichia coli mouse infection model. The first detailed pharmacokinetic and biodistribution parameters were obtained from healthy human volunteers.

Results

The uptake of ¹⁸F-FDS in an E. coli mouse-myositis infection model was easily differentiated from other organs and normal muscle. Intensive lesion uptake declined after antibiotic treatment. In the pilot human study, no adverse effects due to ¹⁸F-FDS were observed up to 24 h post-injection. The radiotracer was rapidly cleared from the circulation and excreted mainly through the urinary system.

Conclusion

We conclude that ¹⁸F-FDS PET holds great potential for appropriate and effective for the imaging of bacterial infections in vivo. These preliminary results indicate that further clinical studies are warranted.