Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents
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- 作者：Cai Linb ; 1 ; Chenghai Suna ; 1 ; Xiao Liua ; Yiqian Zhoub ; Muzammal Hussainb ; c ; Junting Wanb ; Minke Lib ; Xue Lia ; Ruiliang Jine ; Zhengchao Tub ; tu_zhengchao@gibh.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Jiancun Zhangb ; d ; zhang_jiancun@gibh.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：H1N1 ; H3N2 ; Influenza A ; Nucleoside analogs
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：13-20
- 全文大小：1852 K
文摘
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A novel nucleoside scaffold, compound 4, was preparedwith high stereoselectivity.
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26 6-methyl 7-substituted-7-deaza purine nucleoside analogs were synthesized.
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Anti-influenza A virus activity and cytotoxicity evaluation were conducted.
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Three compounds 5r, 5x and 5z showed more potent antiviral activity than Ribavirin.
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5x may serve as a potential lead compound for anti-influenza A drug development.