Arginine modified polymeric micelles as a novel drug delivery system with enhanced endocytosis efficiency
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- 作者：Song Luoa ; b ; 1 ; Yixin Zhanga ; b ; 1 ; Jun Caob ; caojun@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Bin Heb ; Sai Lia ; lisai@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arginine ; Guanidinylation ; PEG-PCL ; DOX ; Competitive binding ; Internalization efficiency
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：181-192
- 全文大小：3021 K
文摘
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Arginine modified poly(ethylene glycol)-b-poly(ε-caprolactone) diblock copolymer was synthesized.
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The effect of arginine on the cellular internalization of drug loaded micelles was investigated.
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The arginine enhanced endolysosome escape of drug loaded polymeric micelles to improve the anticancer activity.