Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells
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- 作者：Shuichi Kitayama1 ; 7 ; Rong Zhang2 ; 6 ; 7 ; Tian-Yi Liu2 ; 3 ; Norihiro Ueda1 ; 2 ; Shoichi Iriguchi1 ; Yutaka Yasui1 ; Yohei Kawai1 ; Minako Tatsumi2 ; Norihito Hirai1 ; Yasutaka Mizoro4 ; Tatsuaki Iwama6 ; Akira Watanabe4 ; Mahito Nakanishi5 ; Kiyotaka Kuzushima2 ; Yasushi Uemura2 ; 6 ; 8 ; yuemura@east.ncc.go.jp" class="auth_mail" title="E-mail the corresponding author ; Shin Kaneko1 ; 8 ; kaneko.shin@cira.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：6
- 期：2
- 页码：213-227
- 全文大小：3679 K
文摘
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Human iNKT cell-derived iPSCs have differentiated into Vα24 iNKT-like cells in vitro
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Re-differentiated iNKT-like (Re-iNKT) cells have functionally recovered properties
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Re-iNKT cells function as an adjuvant to activate antigen-specific CTLs and NK cells
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Re-iNKT cells exert cytotoxic activity via NKG2D- and DNAM-1-dependent mechanism