A chemo-enzymatic synthesis of optically active 1,1-diethoxyethyl(aminomethyl)phosphinates: useful chiral building blocks for phosphinyl dipeptide isosteres

详细信息    查看全文

• 作者：Takehiro  ; Yamagishi^&dagger ; ; Jun-ichirou  ; Mori ; Terumitsu  ; Haruki ; Tsutomu  ; Yokomatsu  ; ;   ; ^{yokomatu@toyaku.ac.jp}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2011
• 出版时间：30 June 2011
• 年：2011
• 卷：22
• 期：12
• 页码：1358-1363
• 全文大小：587 K

文摘

The kinetic resolution of 1,1-diethoxyethyl(hydroxymethyl)phosphinate possessing chirality at the phosphorus atom was achieved via a lipase-catalyzed acylation. The product was transformed into the corresponding imine, which in turn is a useful starting material for the preparation of phosphinyl dipeptide isosteres.