Benzothiazepinecarboxamides: Novel hepatitis C virus inhibitors that interfere with viral entry and the generation of infectious virions
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- 作者：Hee-Young Kima ; 2 ; Sunju Kongb ; 2 ; Sangmi Ohb ; Jaewon Yanga ; Eunji Joa ; Yoonae Koc ; Soo-Hyun Kima ; Jong Yeon Hwangb ; 1 ; Rita Songb ; ; Marc P. Windischa ; marc.windisch@ip-korea.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis C virus (HCV) ; Benzothiazepinecarboxamide (BTC) ; Antiviral activity ; Structure-activity relationship study ; Pharmacophore ; Mechanisms of action (MoA)
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：39-46
- 全文大小：2174 K
文摘
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We identified Benzothiazepinecarboxamides (BTC) as novel hepatitis C virus inhibitor.
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BTC inhibits HCV glycoprotein E1/E2 mediated viral entry and generation of infectious virions.
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Antiviral activity was improved by structure-activity-relationship studies.
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The pharmacophore of BTC was identified, crucial for its antiviral activity, by common pharmacophore hypothesis modeling.