Mutation of rnf213a by TALEN causes abnormal angiogenesis and circulation defects in zebrafish
详细信息 查看全文
- 作者：Jun Wena ; 1 ; Xunsha Suna ; 1 ; Huimin Chena ; Huijiao Liua ; Rong Laia ; Jiaoxing Lia ; Yufang Wanga ; Jingjing Zhangb ; jingjing.zhang@live.com" class="auth_mail" title="E-mail the corresponding author ; Wenli Shenga ; shengwl@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：rnf213a ; TALEN ; Zebrafish ; Angiogenesis ; Circulation
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：1644
- 期：Complete
- 页码：70-78
- 全文大小：2177 K
文摘
- •
We successfully generated rnf213a mutant zebrafish in vivo model for moyamoya disease using TALEN technique.
- •
rnf213a mutant zebrafish developed abnormal angiogenesis in intersegmental vessels and cranial secondary vessels.
- •
rnf213a mutant zebrafish demonstrated circulatory defects in abnormal sprouts in the trunk and head.