A facile and pragmatic electrochemical biosensing strategy for ultrasensitive detection of DNA in real sample based on defective T junction induced transcription amplification
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- 作者：Rui Yuana ; b ; Shijia Dingb ; Yurong Yanb ; Ye Zhangb ; Yuhong Zhanga ; Wei Chenga ; chengwei@cqmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Electrochemical DNA biosensor ; Transcription amplification ; Group B Streptococci ; Signal amplification
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：19-25
- 全文大小：2153 K
文摘
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A simple, highly sensitive and specific electrochemical biosensor was designed by combining with a novel defective junction induced transcription amplification (DTITA).
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The proposed strategy can directly detect target gene from as low as 400 copies of genomic DNA and was successfully applied to directly screening Group B Streptococci from clinical samples.