Homogeneous synthesis of quaternized chitin in NaOH/urea aqueous solution as a potential gene vector
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- 作者：Na Penga ; c ; Ziye Aia ; Zehong Fanga ; Yanfeng Wanga ; Zhiping Xiaa ; Zibiao Zhonga ; Xiaoli Fana ; Qifa Yea ; b ; yqf_china@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Homogeneous synthesis ; Quaternized chitin ; Degree of substitution ; Gene delivery
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：5 October 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：180-186
- 全文大小：1302 K
文摘
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A series of quaternized chitins (QCs) were homogenously synthesized via a simple and “green” process.
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The degree of substitution of QC (0.27–0.54) could be obtained by adjusting the reaction conditions.
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QCs had a good ability of condensing plasmid DNA into compact nanoparticles with the size of 100–200 nm and zeta potential of +18 to + 36 mV.
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The QCs exhibited low cytotoxicity and effective transfection activity.