Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis
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- 作者：Sheng-Xiong Huang ; Quan-Bin Han ; Chun Lei ; Jian-Xin Pu ; Wei-Lie Xiao ; Jun-Lin Yu ; Liu-Meng Yang ; Hong-Xi Xu ; Yong-Tang Zheng ; Han-Dong Sun
- 关键词：Schisandra ; Schisandra nortriterpenoids ; Wuweizidilactone ; Schindilactone ; Wuweizilactone acid
- 刊名：Tetrahedron
- 出版年：2008
- 出版时间：5 May 2008
- 年：2008
- 卷：64
- 期：19
- 页码：4260-4267
- 全文大小：525 K
文摘
Two new bisnortriterpenoids with 18-norschiartane skeleton, wuweizidilactones G (1) and H (2), four new highly oxygenated nortriterpenoids based on a schisanartane skeleton, schindilactones D–G (3–6), a pre-schisanartane skeleton, pre-schisanartanin B (7), and a novel 3,4-seco-21,26-olide-artane triterpenoid wuweizilactone acid (8), along with 24 known terpenoids with different carbon frameworks, have been isolated from the acetone extract of the stems and leaves of Schisandra chinensis. The terpenoids produced by this plant have chemical diversity. The structures of new compounds 1–8 have been characterized by spectroscopic data interpretation. The cytotoxicity and anti-HIV-1 activity of all the Schisandra nortriterpenoids were evaluated.