Elevated expression of T-bet in mycobacterial antigen-specific CD4+ T cells from patients with tuberculosis
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- 作者：Bingfen Yang ; Fei Zhai ; Jing Jiang ; Xinjing Wang ; Zhihong Cao ; Xiaoxing Cheng ; xcheng79@outlook.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tuberculosis ; T-bet ; CD4 T cells
- 刊名：Cellular Immunology
- 出版年：2015
- 出版时间：November-December 2015
- 年：2015
- 卷：298
- 期：1-2
- 页码：1-8
- 全文大小：2970 K
文摘
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T-bet expression in antigen-specific CD4+ T cells was significantly higher in patients with TB.
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Antigen-specific CD4+T-bet+ T cells had higher frequency of TEM than T-bet− cells.
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Expression of PD-1 was higher in CD4+CD154+T-bet+ T cells than CD4+CD154+T-bet− T cells.
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T-bet expression might be associated with differentiation into TEM and PD-1 expression.