Evaluation of a chimeric multi-epitope-based DNA vaccine against subgroup J avian leukosis virus in chickens
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- 作者：Qingqing Xua ; c ; 1 ; Ning Cuia ; 1 ; Xingjiang Maa ; Fangkun Wanga ; b ; Hongmei Lia ; b ; Zhiqiang Shenc ; Xiaomin Zhaoa ; b ; xmzhao66@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Subgroup J avian leukosis virus ; Multi-epitope DNA vaccine ; Prime-boost strategy ; Neutralizing antibodies ; Cellular immune response
- 刊名：Vaccine
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：34
- 期：33
- 页码：3751-3756
- 全文大小：951 K
文摘
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Chimeric multi-epitope gene X was evaluated its potency as a DNA vaccine against ALV-J.
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The DNA vaccine could elicit both neutralizing antibodies and cellular responses.
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The DNA vaccine showed good protection efficacy against ALV-J infection.
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The DNA vaccine in proper prime-boost combination may offer an efficient vaccine strategy against ALV-J.