LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway

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LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway

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作者：Han-xiang Zhan^a ; Yao Wang^b ; ^c ; Ce Li^b ; ^c ; Jian-wei Xu^a ; Bin Zhou^d ; Jian-kang Zhu^a ; Hai-feng Han^a ; Lei Wang^a ; Yun-shan Wang^b ; ^{wangyunshan135@126.com" class="auth_mail" title="E-mail the corresponding author} ; San-yuan Hu^a ; ^{husanyuan1962@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Pancreatic cancer ; LincRNA-ROR ; Epithelial-mesenchymal transition ; ZEB1 ; Metastasis
刊名：Cancer Letters
出版年：2016
出版时间：1 May 2016
年：2016
卷：374
期：2
页码：261-271
全文大小：5084 K

文摘

•: LincRNA-ROR is upregulated in pancreatic cancer (PC) tissues.
•: LincRNA-ROR promotes PC cells proliferation and invasion in vitro, enhanced tumorigenic and metastatic capacities in vivo.
•: LincRNA-ROR enhances ZEB1 expression in PC.
•: LincRNA-ROR mediates EMT, migration, and metastasis in PC may partly by activation of ZEB1 through inhibition of p53.

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