Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker

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• 作者：Maria Guido ; MD^a ; ^{mguido@unipd.it" class="auth_mail" title="E-mail the corresponding author} ; Samantha Sarcognato ; MD^a ; ^{samantha.sarcognato@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Guido Pelletti ; MD^b ; ^{guidopelletti@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Matteo Fassan ; MD ; PhD^a ; ^{matteo.fassan@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bruno Murer ; MD^c ; ^{bruno.murer@ulss12.ve.it" class="auth_mail" title="E-mail the corresponding author} ; Rossella Snenghi ; MD^b ; ^{rossella.snenghi@unipd.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ASL ; liver angiosarcoma ; VC ; vinyl chloride ; HCC ; hepatocellular carcinoma ; MN ; micronucleus ; TASH ; toxicant-associated steatohepatitis
• 刊名：Human Pathology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：193-196
• 全文大小：698 K

文摘

Strong experimental and clinical evidences have definitely linked occupational vinyl chloride exposure to development of angiosarcoma of the liver. In contrast, despite the International Agency for Research on Cancer having included vinyl chloride among the causes of hepatocellular carcinoma, the association between vinyl chloride exposure and hepatocellular carcinoma remains debated. This issue is relevant, because occupational exposure to high levels of vinyl chloride may still occur. We report a unique case of sequential occurrences of hepatocellular carcinoma and angiosarcoma of the liver, in a vinyl chloride–exposed worker without cirrhosis and any known risk factor for chronic liver disease. Both the hepatocellular carcinoma and the surrounding normal liver showed micronucleus formation, which reflects genotoxic effect of vinyl chloride. Angiosarcoma showed a KRAS G12D point mutation, which is considered to be characteristic of vinyl chloride–induced angiosarcoma. This case supports the pathogenic role of vinyl chloride in both hepatocellular carcinoma and angiosarcoma development.