Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters

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• 作者：Rodrigo Ruano ; Marie-Cé ; cile Aubry ; Bruno Barthe ; Delphine Mitanchez ; Yves Dumez ; Alex ; ra Benachi
• 关键词：Pulmonary arteries ; Congenital diaphragmatic hernia ; Fetal lung ; Pulmonary hypoplasia ; Fetal malformation ; Predictors of mortality
• 刊名：Journal of Pediatric Surgery
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：43
• 期：4
• 页码：606-611
• 全文大小：315 K

文摘

Objective

The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH).

Study Design

In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH.

Results

The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls (P < .001) and in fetuses with CDH who died (P < .050). However, there was no significant association between PA diameters and PAH (P ≥ .050).

Conclusions

The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.