刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:January 2017
年:2017
卷:1861
期:1
页码:3399-3405
全文大小:542 K
卷排序:1861
文摘
Linoleamide and oleamide inhibit the Ca2+-ATPase activity of three SERCA isoforms. Other primary fatty acid amides (PFAAs) tested hardly inhibit SERCA activity. The IC50 of SERCA inhibition is ≤ 53 μM for linoleamide and ≤ 34 μM for oleamide. Dissociation constants for the SERCA–PFAA interactions vary from 1.6 to 55 μM. Linoleamide and oleamide act in lowering the apparent Ca2+ affinity of SERCA.