Opposite Associations Between the rs3845446 Single-Nucleotide Polymorphism of the CACNA1E Gene and Postoperative Pain-Related Phenotypes in Gastrointestinal Surgery Versus Previously Reported Orthognathic Surgery
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- 作者：Kojiro Amano&lowast ; ; &dagger ; ; Daisuke Nishizawa&lowast ; ; Tsutomu Mieda&Dagger ; ; Miki Tsujita&Dagger ; ; Akira Kitamura&Dagger ; ; Junko Hasegawa&lowast ; ; Eiichi Inada&dagger ; ; Masakazu Hayashida&dagger ; ; &Dagger ; ; Kazutaka Ikeda&lowast ; ; ikeda-kz@igakuken.or.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CACNA1E ; Cav2.3 ; single-nucleotide polymorphism ; postoperative pain ; gastrointestinal surgery
- 刊名：The Journal of Pain
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：17
- 期：10
- 页码：1126-1134
- 全文大小：532 K
文摘
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Pain-related phenotypes (PP; analgesic requirements or pain scores) were examined.
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The rs3845446 single nucleotide polymorphism (SNP) was genotyped in the subjects.
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The G allele of the rs3845446 SNP enhanced PP after gastrointestinal surgery (GS).
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Association of the SNP with PP after GS opposed to that after orthognathic surgery.
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30">Cav2.3 channel functions might differentiate PP after GS and orthognathic surgery.