The effect of oleuropein from olive leaf (Olea europaea) extract on Ca2+ homeostasis, cytotoxicity, cell cycle distribution and ROS signaling in HepG2 human hepatoma cells
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- 作者：Jin-Shiung Chenga ; Chiang-Ting Choub ; c ; Yuan-Yuarn Liud ; Wei-Chih Sune ; Pochuen Shiehf ; Daih-Huang Kuof ; Chun-Chi Kuog ; Chung-Ren Janh ; Wei-Zhe Liangh ; lianggoole67@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Ca2+ ; Cell cycle ; Human hepatoma cells ; Oleuropein ; ROS
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：151-166
- 全文大小：2798 K
文摘
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The investigation of oleuropein-induced [Ca2+]i rises and cytotoxicity was explored in liver cells.
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Oleuropein induced [Ca2+]i rises by releasing Ca2+ and causing Ca2+ influx in HepG2 cells.
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Oleuropein induced Ca2+-associated apoptosis in HepG2 cells.
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Oleuropein evoked ROS signaling and cell cycle arrest in HepG2 cells.