Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth

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• 作者：Chad Hall^d ; Laurent Ehrlich^c ; ^d ; Julie Venter^c ; April O'Brien^a ; Tori White^a ; Tianhao Zhou^c ; ^e ; Tien Dang^b ; Fanyin Meng^b ; Pietro Invernizzi^f ; ¹ ; Francesca Bernuzzi^f ; ¹ ; Gianfranco Alpini^a ; ^b ; ^c ; ^d ; Terry C. Lairmore^d ; Shannon Glaser^a ; ^b ; ^c ; ^{sglaser@medicine.tamhsc.edu}
• 关键词：Apelin ; Apelin receptor ; Cholangiocarcinoma ; Biliary epithelium ; Proliferation
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：179-188
• 全文大小：3517 K
• 卷排序：386

文摘

Expression of the apelin/apelin receptor axis is upregulated in cholangiocarcinoma. Inhibition of apelin receptor signaling inhibits cholangiocarcinoma proliferation and angiogenesis. Targeting the apelin receptor axis could provide novel, tumor directed therapies to inhibit cholangiocarcinoma progression.