Association between preterm delivery and subsequent C-reactive protein: a retrospective cohort study

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• 作者：Claire E. Hastie ; PhD^a ; Gordon C.S. Smith ; PhD^c ; Daniel F. Mackay ; PhD^b ; Jill P. Pell ; MD^b ; ^{Jill.Pell@glasgow.ac.uk}
• 关键词：cardiovascular risk prediction ; inflammation ; preterm births
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2011
• 出版时间：December, 2011
• 年：2011
• 卷：205
• 期：6
• 页码：556.e1-556.e4
• 全文大小：238 K

文摘

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Objective

We sought to determine whether giving birth preterm is associated with raised maternal C-reactive protein (CRP) in later life and whether the association is specific to indicated or spontaneous delivery.

Study Design

This was a Scotland-wide retrospective cohort study of 1124 women who had a first pregnancy resulting in a singleton, liveborn infant delivered between 24-43 weeks' gestation. Linear regression analysis was used to examine the association between preterm delivery and subsequent CRP concentration.

Results

The difference in CRP between women who delivered term and preterm was nonsignificant on univariate analysis (beta coefficient 0.04, P = .18) but was statistically significant following adjustment for potential confounders (beta coefficient 0.05, P < .05). On subgroup analysis the association was specific to women who had had indicated preterm delivery (unadjusted beta coefficient 0.09, P < .01; adjusted beta coefficient 0.09, P < .01).

Conclusion

Women who undergo indicated preterm delivery are at increased risk of raised CRP in later life.