文摘
Oxamate, aminooxyacetate (AOA) and dichloroacetate (DCA) are not specific drugs. Oxamate, AOA and DCA inhibit several glycolytic and OxPhos enzymesOxamate inhibition induces Fru1,6BP and DHAP accumulation. High Fru1,6BP and DAHP levels inhibit HK, HPI, TPI and GAPDH activities. Kinetic modeling shows that oxamate must affect several enzymes to block glycolysis.