A novel and simple procedure for the enantiospecific synthesis of bridgehead norbornane thioethers and thiocyanates

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• 作者：Garcí ; a Martí ; nez ; Antonio ; Teso Vilar ; Enrique ; Moreno Jim&eacute ; nez ; Florencio ; et. al.
• 刊名：Tetrahedron: Asymmetry
• 出版年：2002
• 出版时间：December 9, 2002
• 年：2002
• 卷：13
• 期：2
• 页码：2635-2639
• 全文大小：185 K

文摘

An easy three-step route for the enantiospecific synthesis of novel 1-norbornyl thioethers and thiocyanates from readily available natural fenchone and camphor is described. The key step of the synthetic route is the nucleophilic substitution over the sulfenyl sulfur atom of the intermediate thiotriflates by the corresponding C-nucleophiles.