Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses

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• 作者：Gaudieri ; Silvana ; Nolan ; David ; McKinnon ; Elizabeth ; Witt ; Campbell S. ; Mallal ; Simon ; Christiansen ; Frank T.
• 关键词：NK cells ; KIR epitopes ; HLA ; HIV infection
• 刊名：Molecular Immunology
• 出版年：2005
• 出版时间：February, 2005
• 年：2005
• 卷：42
• 期：4
• 页码：557-560
• 全文大小：63.6 K

文摘

The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens.