Autopsy findings in fatal dengue haemorrhagic fever - 06 Cases

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• 作者：K.R. Rathi ; M.M. Arora ; K. Sahai ; S. Tripathi ; S.P. Singh ; D.K. Raman ; K.B. An
• 关键词：Dengue haemorrhagic fever ; Autopsy ; Pathophysiology
• 刊名：Medical Journal Armed Forces India
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：69
• 期：3
• 页码：254-259
• 全文大小：1177 K

文摘

Background

During recent outbreak of dengue fever in Delhi, there has been a significant increase in dengue-associated admission in hospitals. To better understand the pathology of dengue haemorrhagic fever, we conducted autopsies of dengue infections deaths within our hospital.

Method

This was an autopsy study of dengue-associated deaths at a large tertiary care hospital.

Results

From Sep 2009 to Dec 2010, a total of 1032 patients with serological evidence of dengue infection were admitted to our hospital. There were twelve deaths and autopsies were conducted in six. Adult respiratory distress syndrome, bleeding diathesis, hypotension, hepatic failure and acute renal failure were the common causes of death despite early hospitalization, intravenous fluid, and blood-product support.

Conclusion

Dengue is associated with severe disease, and deaths do occur despite current supportive management. Early predictors of disease severity and better clinical interventions are needed.