Structural insight into human CK2α in complex with the potent inhibitor ellagic acid
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- 作者：Yusuke Sekiguchi ; Tetsuko Nakaniwa ; Takayoshi Kinoshita ; Isao Nakanishi ; Kazuo Kitaura ; Akira Hirasawa ; Gozoh Tsujimoto ; Toshiji Tada
- 关键词：CK2 ; Crystal structure ; Structure-based drug design ; Ellagic acid
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：1 June 2009
- 年：2009
- 卷：19
- 期：11
- 页码：2920-2923
- 全文大小：447 K
文摘
We determined the 2.35-Å crystal structure of a human CK2 catalytic subunit (referred to as CK2α complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2α with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.