Bombyx DHR is activated by DH via a Gq protein-dependent Pathway.
Activated BmDHR induces ERK1/2 phosphorylation in a dose- and time-dependent manner.
BmDHR triggers ERK1/2 activation through Gq-dependent cascade.
Gβγ and PI3K are involved in BmDHR-mediated activation of ERK1/2.
EGFR and Src are unlikely to implicate in BmDHR-induced ERK1/2 phosphorylation.