Evaluation of cytokine and chemokine response elicited by Rv2204c and Rv0753c to detect latent tuberculosis infection
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- 作者：Balaji Pathakumari ; Maddineni Prabhavathi ; Alamelu Raja ; alameluraja@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：M. tb ; Mycobacterium tuberculosis ; LTBI ; latent tuberculosis infection ; WHO ; World Health Organization ; DOTS ; directly observed treatment short course ; TST ; Tuberculin skin test ; IGRA ; Interferon-Gamma Release Assay ; PPD ; purified protein derivative ; NTM ; non-tuberculosis mycobacterium ; LB ; Luria&ndash ; Bertani ; IPTG ; isopropyl-1-thio-尾-d-galacto-side ; ESAT-6 ; early secreted antigen target-6 ; CFP-10 ; culture filtrate protein-10 ; mmsA ; methyl malonate semialdehyde dehydrogenase ; E. coli ; Escherich
- 刊名：Cytokine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：76
- 期：2
- 页码：496-504
- 全文大小：1137 K
文摘
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This is the first study to report the immunogenicity of Rv2204c antigen in latent and active tuberculosis.
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Rv2204c and Rv0753c antigen-specific IFN-纬 response and IFN-纬/TNF-伪 ratio appeared to be diagnostically useful for identifying LTBI.
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In this study, we are reporting specific marker for latent tuberculosis in high endemic settings, where background infection is high.
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The outcome of the study has a potential to be implemented in clinical laboratories in resource-constrained settings.