Aryl group - a leaving group in arylphosphine oxides
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- 作者：Marek Stankevič ; marek.stankevic@poczta.umcs.lublin.pl" class="auth_mail" title="E-mail the corresponding author ; Jolanta Pisklak ; Katarzyna Włodarczyk
- 关键词：Nucleophilic substitution ; Phosphine derivatives ; Organolithium compounds ; Grignard reagents ; Selectivity
- 刊名：Tetrahedron
- 出版年：2016
- 出版时间：11 February 2016
- 年：2016
- 卷：72
- 期：6
- 页码：810-824
- 全文大小：1134 K
文摘
The treatment of triphenylphosphine oxide with organometallic reagents leads to the substitution of up to three phenyl substituents with the incoming carbon nucleophile. The replacement of the phenyl/aryl group in tertiary diarylalkylphosphine oxides or even aryldialkylphosphine oxides was also observed. Naphthyl-substituted phosphine oxides undergo Michael-type addition at the naphthyl group when treated with organolithium reagent.