刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:February 2017
年:2017
卷:1863
期:2
页码:607-619
全文大小:2200 K
卷排序:1863
文摘
Multitarget binding properties of 7-methoxytacrine - memantine heterodimers were tested. 7-methoxytacrine - memantine heterodimers inhibit Aβ peptide amyloid fibrillization. Heterodimers inhibit β-secretase activity depending on thiourea or urea linker length. Heterodimers act as antagonists for both M1 muscarinic and muscle-type nicotinic receptors. Heterodimers don't potentiate cholinergic transmission via the direct interaction with cholinergic receptors.