Waddlia: An emerging pathogen and a model organism to study the biology of chlamydiae

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• 作者：Fré ; deric Lamoth ; Trestan Pillonel ; Gilbert Greub ; ^{gilbert.greub@chuv.ch" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Emerging pathogen ; Intracellular bacteria ; Chlamydia-like organism ; Miscarriage ; Model organism
• 刊名：Microbes and Infection
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：17
• 期：11-12
• 页码：732-737
• 全文大小：1115 K

文摘

m>Waddlia chondrophilam> is an emerging pathogen associated with abortion in cattle. In humans, a growing body of evidence supports its pathogenic role in miscarriage and in respiratory tract infection. The human pathogenicity of m>W. chondrophilam> is further supported by the presence of several virulence factors including a catalase, a functional T3SS and several adhesins. Despite this medical importance, no commercial tests are available and diagnostic of this strict intracellular bacterium mainly relies on serology, PCR and immunohistochemistry. So far, the epidemiology of m>W. chondrophilam> remains largely unexplored and zoonotic, waterborne or interhuman transmission has been considered.

Apart from its pathogenic role, chlamydiologists are also interested in m>W. chondrophilam> in order to better understand biological mechanisms conserved and shared with m>Chlamydiam> spp. Indeed, m>W. chondrophilam> proved to be a useful model organism to study the pathobiology of chlamydiae thanks to its rapid replication, its large size allowing precise subcellular protein localization, as well as its growth in m>Dictyosteliumm> amoebae.