刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1025-1029
全文大小:887 K
卷排序:482
文摘
We found that knock-down of PLCγ1 induced foreign body giant cell formation. PLCγ1 knock-down upregulates the expression of fusogenic genes. RUNX1 suppresses foreign body giant cell formation. PLCγ1 regulates the RUNX1/PU.1/DC-STAMP axis in macrophages. The finding suggests that PLCγ1 plays a role in the foreign body response.