Risk Factors for Prosthetic Pulmonary Valve Failure in Patients With Congenital Heart Disease

详细信息    查看全文

• 作者：Jose Maria Oliver ; MD ; PhD^a ; ^b ; ^{joliver@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author} ; Diego Garcia-Hamilton ; MD^a ; ^c ; Ana Elvira Gonzalez ; MD^a ; ^c ; Jose Ruiz-Cantador ; MD^a ; ^c ; Angel Sanchez-Recalde ; MD^a ; ^c ; Maria Luz Polo ; MD ; PhD^a ; ^d ; Angel Aroca ; MD^a ; ^d
• 刊名：The American Journal of Cardiology
• 出版年：2015
• 出版时间：15 October 2015
• 年：2015
• 卷：116
• 期：8
• 页码：1252-1256
• 全文大小：696 K

文摘

The incidence and risk factors for prosthetic pulmonary valve failure (PPVF) should be considered when determining optimal timing for pulmonary valve replacement (PVR) in asymptomatic patients with congenital heart disease (CHD). The cumulative freedom for reintervention due to PPVF after 146 PVR in 114 patients with CHD was analyzed. Six potential risk factors (underlying cardiac defect, history of palliative procedures, number of previous cardiac interventions, hemodynamic indication for PVR, type of intervention, and age at intervention) were analyzed using Cox proportional hazard modeling. Receiver operating characteristic (ROC) curves were used for discrimination. Internal validation in patients with tetralogy of Fallot was also performed. Median age at intervention was 23 years. There were 60 reinterventions due to PPVF (41%). Median event-free survival was 14 years (95% confidence interval [CI] 12 to 16 years). The only independent risk factor was the age at intervention (hazard ratio [HR] 0.93, 95% CI 0.90 to 0.97; p = 0.001; area under the ROC curve 0.95, 95% CI 0.92 to 0.98; p <0.001). The best cut-off point was 20.5 years. Freedom from reintervention for PPVF 15 years after surgery was 70% when it was performed at age >20.5 years compared with 33% when age at intervention was <20.5 years (p = 0.004). Internal validation in 102 PVR in patient cohort with tetralogy of Fallot (ROC area 0.98, 95% CI 0.96 to 1.0; p <0.001) was excellent. In conclusion, age at intervention is the main risk factor of reintervention for PPVF. The risk of reintervention is 2-fold when PVR is performed before the age of 20.5 years.