Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands
A set of eight novel mixed-ligand vanadium complexes are synthesized and characterized. The V complexes depict no or very low DNA-cleavage activity. Subcellular distribution indicates that compounds target different cellular components. Compounds produce membrane alterations, nuclear atypia and mitochondria densification.