Convulsant effect of diphenyl diselenide in rats and mice and its relationship to plasma levels
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- 作者：Marina Prigol ; Ricardo F. Schumacher ; Cristina WayneNogueira ; Gilson Zeni
- 关键词：Diphenyl diselenide ; Administration route ; Vehicle solution ; Selenium ; Toxicity ; Plasma
- 刊名：Toxicology Letters
- 出版年：2009
- 出版时间：25 August 2009
- 年：2009
- 卷：189
- 期：1
- 页码：35-39
- 全文大小：238 K
文摘
Diphenyl diselenide [(PhSe)2], an organoselenium compound, presents pharmacological and toxicological properties in rodents. The aim of this study was to carry out the determination and quantification of (PhSe)2 in plasma after oral administration (p.o.) of this compound (500 mg/kg), dissolved in canola oil, in rats and mice. The second objective was to verify the involvement of different routes of administration ((p.o.), intraperitoneal (i.p.) and subcutaneous (s.c.)) and vehicle solutions (canola oil and dimethyl sulfoxide (DMSO)) in the appearance of seizure episodes and in the plasmatic levels of (PhSe)2 in rats and mice. Analysis of (PhSe)2 in blood samples was performed by gas chromatography/flame ionized detector system (GC/FID). Rat and mouse peak plasma (PhSe)2 levels were 13.13 and 10.11 μg/ml (Cmax), respectively, and occurred at 0.5 h (Tmax) post-dosing. The use of different administration routes (p.o., i.p. and s.c.) and vehicle solutions (canola oil or DMSO) in rats and mice indicated that the appearance of seizures and (PhSe)2 plasmatic levels are dependent of administration routes (i.p. > p.o. > s.c.), vehicle solutions (DMSO > canola oil) and animal species (mice > rat).