- 作者：Manik Lal Thakur ; Sanjay Sharma ; Atin Kumar ; Surya Prakash Bhatt ; Kalpana Luthra ; R ; eep Guleria ; Ravindra M. P ; ey ; Naval K. Vikram
- 关键词：NAFLD ; Atherosclerosis ; Endothelial dysfunction ; Asian Indians
- 刊名：Atherosclerosis
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：223
- 期：2
- 页码：507-511
- 全文大小：198 K
Objective
We examined the association of subclinical atherosclerosis and endothelial dysfunction with nonalcoholic fatty liver disease (NAFLD) in Asian Indians.Methods
This study included 40 non-diabetic subjects with NAFLD and 40 apparently healthy controls without NAFLD with similar age, gender and body mass index. Measurements included anthropometric parameters, oral glucose tolerance test, fasting and 2?h insulin, lipid profile, C-reactive protein, sICAM-1, VCAM-1, carotid intima-media thickness (CIMT) and brachial artery flow mediated dilatation (FMD).
Results
Subjects with NAFLD had higher average and maximum CIMT (0.6?¡À?0.12 and 0.684?¡À?0.16?mm, respectively, vs 0.489?¡À?0.1 and 0.523?¡À?0.1?mm, respectively; p?<?0.05), and had higher prevalence of atherosclerotic plaques (20 % vs 5 % , p?<?0.05) than controls. Significantly greater degree of impairment in FMD and higher levels of hs-CRP and sICAM-1 were observed in NAFLD patients than controls. The presence of NAFLD was observed to be the independent predictor of having high average CIMT (OR 4.8; 95 % CI: 1.8-12.8), high maximum CIMT (OR 5.4; 95 % CI: 2.0-14.4) and impaired FMD (OR 11.7; 95 % CI: 1.4-96.5) even after adjusting for obesity, metabolic syndrome, insulin resistance and lipid parameters.
Conclusion
In Asian Indians NAFLD is significantly associated with subclinical atherosclerosis and endothelial dysfunction independent of obesity and metabolic syndrome. Elevated levels of hs-CRP and sICAM-1 may be useful as indicators of liver injury in NAFLD.